Intravenous Self-administration (IVSA): IVSA serves as a translational model for drug abuse, closely resembling human behavior. By implanting a catheter into the venous system, this allows for acute chronic drug administration. Subjects learn to lever press, to self administer drugs, in an operant chamber. We are one of the few laboratories in the world capable of effectively using this model.
Electrophysiology: We assess the function and adaptations of individual cells of the peripheral and central nervous systems by electrophysiology. We use an inverted microscope coupled with fast perfusion systems for acutely disassociated cells and a slicescope system (Scientifica) for slice recordings.