Intravenous Self-administration (IVSA): IVSA serves as a translational model for drug abuse, closely resembling human behavior. By implanting a catheter into the venous system, this allows for acute chronic drug administration. Subjects are trained to lever press in an operant chamber to self administer drugs. We are one of the few laboratories in the world capable of effectively using this model.

Intravenous Self-administration (IVSA): IVSA serves as a translational model for drug abuse, closely resembling human behavior. By implanting a catheter into the venous system, this allows for acute chronic drug administration. Subjects learn to lever press, to self administer drugs, in an operant chamber. We are one of the few laboratories in the world capable of effectively using this model.


Cell and Circuit Connectivity: We use a viral tracing protocol to assess the effects of pain and addiction on connectivity of neural networks. Using a retrogradely transported rabies or pseudorabies virus we can assess the adaptations of specific cells of the striatum and their afferent connections. We have developed a computer algorithm to count labeled cells, then to register each cell to the Allen Brain Atlas and output the number of labeled cells throughout the brain. 

Cell and Circuit Connectivity: Using a retrograde virus, we are able to trace connectivity of neural circuits. This allows us to assess the effects of pain and addiction on a network scale in the brain. We have developed a computer algorithm which counts labeled cells and registers them to brain regions using the Allen Brain Atlas. Click here to download the algorithm program and associated files!

Electrophysiology: We assess the function and adaptations of individual cells of the peripheral and central nervous systems by electrophysiology. We use an inverted microscope coupled with fast perfusion systems for acutely disassociated cells and a slicescope system (Scientifica) for slice recordings.

Electrophysiology: We assess the function and adaptations of individual cells of the peripheral and central nervous systems by electrophysiology. We use an inverted microscope coupled with fast perfusion systems for acutely disassociated cells and a slicescope system (Scientifica) for slice recordings.


Optogenetics: We use optogenetics to activate specific cells and study the behavioral and cellular consequences of addiction and pain. We are currently developing an open-source and affordable wireless optogenetic probe.

Optogenetics: We use optogenetics to activate specific cells and study the behavioral and cellular consequences of addiction and pain. We are currently developing an open-source and affordable wireless optogenetic probe.

Optogenetic printed circuit board (PCB) with battery: This is one of our first designs of the wireless optogenetic device, which is controlled with a computer, and communicates with IR. We are currently developing an affordable, open-source and revolutionaryaffordable wireless optogenetic probe which communicates via bluetooth.

Optogenetic printed circuit board (PCB) with battery: This is one of our first designs of the wireless optogenetic device, which is controlled with a computer, and communicates with IR. We are currently developing an affordable, open-source and revolutionaryaffordable wireless optogenetic probe which communicates via bluetooth. Click here for our available downloads to begin making your own!


CLARITY: We use CLARITY to process and view thick tissue sections in three dimensions so as to assess the effect of pain and opioid addiction on cell structure and connectivity.

CLARITY: We use CLARITY to process and image thick tissue sections in three dimensions so as to assess the effect of pain and opioid addiction on cell structure and connectivity.


Neuropathic pain: We use both the cuff and CFA models of chronic pain to study the emotional effects of chronic pain. We use the Von Frey Assay to study mechanical allodynia, an evoked response. We use behavioral tests to assess the affective component of chronic pain.

Neuropathic pain: We use both the cuff and CFA models of chronic pain to study the emotional effects of chronic pain. We use the Von Frey Assay to study mechanical allodynia, an evoked response. We use behavioral tests to assess the affective component of chronic pain.